Handbook of Systems Biology: Concepts and Insights by Marian Walhout, Marc Vidal, Job Dekker

By Marian Walhout, Marc Vidal, Job Dekker

This e-book offers an access element into platforms Biology for researchers in genetics, molecular biology, telephone biology, microbiology and biomedical technology to appreciate the foremost options to increasing their paintings. Chapters equipped round broader topics of Organelles and Organisms, structures houses of organic methods, mobile Networks, and platforms Biology and disorder talk about the advance of recommendations, the present purposes, and the long run customers. Emphasis is put on options and insights into the multi-disciplinary nature of the sphere in addition to the significance of platforms biology in human organic examine. expertise, being a really very important element of clinical development total, and within the production of recent fields specifically, is mentioned in 'boxes' inside each one bankruptcy to narrate to acceptable subject matters.

  • 2013 Honorable Mention for Single quantity Reference in Science from the organization of yank Publishers' PROSE Awards
  • Emphasizes the interdisciplinary nature of platforms biology with contributions from leaders in numerous disciplines
  • Includes the most recent learn advancements in human and animal types to aid with translational research
  • Presents organic and computational features of the technological know-how side-by-side to facilitate collaboration among computational and organic researchers

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Additionally, the list of known molecular components of cellular systems, including nucleic acids, gene products and metabolites, is lengthening and becoming increasingly detailed. With these advances came a humbling realization, best summed up as ‘too much data, too few drugs’ (see Chapter 8). It has become clearer than ever that knowing everything there is to know about each biomolecule in the cell is not sufficient to predict how the cell will react as a whole to particular external or internal perturbations.

The latest release (February 2012) of the UCSC genes includes 80 922 transcripts corresponding to 31 227 genes. Manual annotation still plays a significant role in annotating high-quality finished genomes. Currently the National Center for Biotechnology Information (NCBI) reference sequences (RefSeq) collection provide a highly manually curated resource of multispecies transcripts and includes plant, viral, vertebrate and invertebrate sequences [51,52]. These are, as their name indicates, transcript orientated and usually rely on full-length cDNAs for reliable curation, although the dataset also contains predictions using ESTs and partial cDNAs aligned against genomic sequence using the Gnomon prediction program.

Microarray analyses have achieved more consistent coverage of tissues, but are constrained in their limited ability to distinguish closely related mRNA isoforms, and their inability to identify novel transcribed elements. RNASeq has the potential to circumvent these limitations. Recent RNASeq analysis performed in 15 different cell lines and subcellular compartments in the context of the ENCODE project provides a rich unbiased survey of the transcriptional landscape of the human genome [80]. These analyses reveal that, within a given cell line, on average expression is detected for about 40% of the genes.

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