By Isaac S. Kohane
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E. (1974) 1063. H. and Berg, P. Sei. S. 69 (1972) 2904. J. Virol. 14 Proc. Nat. Acad. E. D. J. Mol. Biol. 78 (1973) 453. (42) Federal Register. Part II: Department of Health, Education and Welfare, National Institutes of Health. Recombinant DNA Research Guidelines. Wednesday, July, 7, 1976. , and Berg, P. Science (1977) in press. C. J. Mol. Biol. (1976) in press. (45) Berg, P. et al. Science 185 (1974) 303. DNA CLONING AND PLASMID BIOLOGY STANLEY N. Y. A. Although :he earliest DNA cloning experiments were reported little more than three years ago, molecular cloning of recombinant DNA has since become an important tool for the study of proka::yotic and eukaryotic biology.
C. L. W. Boyer, submitted publication. for DISCUSSION L. KODITSCHECK: I believe you said that in some cases there was more than one replicating site in a plasmid, is that right? Does that have any relation to the number of copies of the plasmid per cell? N. COHEN: No, it does not appear to. However, the pSC134 plasmid is a composite of pSClOl plus ColEl. Ken Timmis, and Felipe Cabello in my laboratory show that this plasmid ordinarily used only its ColEl replication system, and its copy number is maintained at the copy number of ColEl.
Of course DNA segments with their own transcription promoters and terminators can circumvent the effect of the dA:dT outer segments. Alternatively expression of such segments might be "turned on" by deleting either of the two dA:dT stretches. BIOCHEMICAL PASTIMES . . AND FUTURE TIMES 29 SVGT-1 is only the first, the Mark I, of the potential SV40 transducing vectors. Various segments of the SV40 genome containing the origin of DNA replication are being tested as cloning vectors. Quite possibly, only the 100-200 base pair segment containing the origin of DNA replication could serve to propagate foreign DNA.