Molecular Chaperones by R. J. Ellis (auth.), R. J. Ellis, R. A. Laskey, G. H.

By R. J. Ellis (auth.), R. J. Ellis, R. A. Laskey, G. H. Lorimer (eds.)

Currently one of many preferred issues in biochemistry, the concept that of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in lots of disciplines overview all elements of molecular chaperones during this quantity, which arises from a Royal Society dialogue assembly. evaluate chapters speak about the importance of chaperones in biochemistry, molecular genetics and mobilephone biology. each one bankruptcy is easily referenced delivering entry to the literature.

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55, 1151-1191. Lindquist, S. A. 1986 The heat-shock proteins. A. Rev. Genet. 22, 631-677. The role oj heat-shock proteins in thermo tolerance Nover, L. 1991 Heat shock response, 1st edn. Boca Raton, Florida: CRC Press. D. & Lindquist, S. 1991 Hsp 104 is a highly conserved protein with two essential nucleotide-binding sites. Nature, Lond. 353, 270273. R. 1986 Speculations on the functions of the major heat shock and glucose-regulated proteins. Cell 46, 959-961. Sanchez, Y. L. 1990 HSP 104 required for induced thermotolerance.

EEEWKA .. VE .. H ... MPV .. GK .. ELE .. VL .. W..... SRMM ... R... LR .. ESVV .. IAR .. I. NE. VD ..... R .. A... IG ...... PT. V..... DSDEA. V. M .. FM .. HS .. R. APP ..... E... Y.. F .. DK .. A .. VG .... V .... M .. RHT .. APP .... Q .. L.. D Hsp104 QLQYKPYSVLLFDEVEKAHPDVLTVMLQMLDDGRITSGQGKTIDCSNCIVlMTSNLGAEFlNS---------QQGSKlQESTKNLVMGAVRQHFRPEFLN Clp B AVRRR .... I. L.......... FNlL .. V..... L. D... R. V. FR. TV ........ SDL. QE---------RF. ELDYAHM. E. L. V. SHN ..... I. HA ... L.. I .......

Q .. L.. D Hsp104 QLQYKPYSVLLFDEVEKAHPDVLTVMLQMLDDGRITSGQGKTIDCSNCIVlMTSNLGAEFlNS---------QQGSKlQESTKNLVMGAVRQHFRPEFLN Clp B AVRRR .... I. L.......... FNlL .. V..... L. D... R. V. FR. TV ........ SDL. QE---------RF. ELDYAHM. E. L. V. SHN ..... I. HA ... L.. I ....... FNIL .. VVLV .. T ... R. Hsp104 RISSIVlFNKLSRKAIHKIVDIRLKEIEERFEQNDKHYKLNLTQEAKDFLAKYGYSDDMGARPLNRLIQNElLNKLALRILKNEIKDKETVNVVLKKGKS Clp B .. Q .. EIHISD .. SEN .. DPVY ..... A .. P .. QQ .. DH .. TDV .. QV .. EVS ... RNW .. EK ..

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